On start
From Scriptwiki
The on START event triggers the first time a script file is ever loaded and also every time after that when when mIRC is run.
on <level>:START:<commands>
You can use this event to execute everything you want to do whenever you start your mIRC (e.g. loading dialogs, connecting to several servers, updating some stats, creating and loading data in hash tables).
Example
on *:START: { echo -s Connecting to QuakeNet server irc.quakenet.org:6667 }
This example would make mIRC connect to QuakeNet whenever you start it.
See Also
Take a look at the On load event when you want to trigger when a script file is loaded the first time.