On start
From Scriptwiki
The on START event triggers the first time a script file is ever loaded and also every time after that when when mIRC is run.
on <level>:START:<commands>
You can use this event to execute everything you want to do whenever you start your mIRC (e.g. loading dialogs, connecting to several servers, updating some stats).
Example
on *:START: { echo -s Connecting to QuakeNet server irc.quakenet.org:6667 }
This example would make mIRC connect to QuakeNet whenever you start it.
See Also
Take a look at the On load event when you want to trigger when a script file is loaded the first time.